Hartmut Derendorf Young Scientists Award

The inception of the “Hartmut Derendorf Young Scientists Award” (HDYSA) at the Marbach DDI meeting 2021 was to pay a special tribute in memoriam of our Workshop Co-founder and Faculty colleague Professor Hartmut Derendorf by the Marbach community on an annual basis.

This meant, that from 2021 onwards, the Faculty would identify and nominate each year 2–3 suitably qualified candidates. Upon the agreement of the nominees to participate in the final laureate selection procedure, this will be accomplished by a blinded poll of all speakers and registered workshop attendees using an electronic form at the Marbach DDI Website in advance of the meeting. The elected laureate will then be entitled to present the “Hartmut Derendorf Young Scientists Award Lecture”, and will receive a certificate and a trophy along with a certain financial support (trophy money of 3,000 $) for his/her scientific work.

For financial support of the annual Award, donations will be accepted. Details on how this can be done will be provided by the Workshop Secretary upon request.

Robert Hermann & Shawn Pei Feng Tan

Shawn Pei Feng Tan was selected as the 4th Hartmut Derendorf Young Scientists Award Winner

At the 14th Marbach Castle DDI Workshop, Shawn Pei Feng Tan, BSc in Pharmacy (National University of Singapore), and final year PhD candidate in Translational Pharmacokinetics (University of Manchester) was selected by the 15 member jury panel of Marbach DDI as the 4th recipient of Hartmut Derendorf Young Scientists Award (HDYSA).

His awarded lecture entitled “Modelling Endogenous Biomarkers of Renal OAT1/3 to Assess Transporter-Mediated DDI in Healthy and Patients with Chronic Kidney Disease” focused approaches to tease out the role of transporters and active renal excretion from other processes and highlighted the role of albumin in facilitating active transport as well.

Despite very young age, Shawn has done several seminal work the area of physiologically-based pharmacokinetics (PBPK) in general, and in renal impairment modelling in particular. He had two 1st author publications prior to initiating his PhD and his research has been recognised by ISSX (International Society of Xenobiotics) and ASCPT (American Society of Clinical Pharmacology and Therapeutics) through awards for his presentations. Shawn is member of steering committee of the ISSX transporter focus group and one of the juries of HDYS Award put it: “a rising star” in the horizon of mechanistic modelling of transporter mediated kinetics. HDYS Award was well deserved for this hard working scientist.

Amin Rostami-Hodjegan & Kenta Yoshida

Doctor Kenta Yoshida Nominated as the Third Hartmut Derendorf Young Scientists Award Winner

At the 13th Marbach Castle DDI Workshop, Kenta Yoshida, Ph.D. in Pharmaceutical Sciences and Senior Principal Scientist (M&S), Clinical Pharmacology at Genentech Research and Early Development was nominated by the Marbach DDI jury as the third Hartmut Derendorf Young Scientists Award (HDYSA) Winner.

His awarded lecture entitled “Industry Applications and Kinetic Considerations of Transporter Endogenous Biomarkers” focused on industry applications of endogenous biomarkers coupled with PBPK modeling for the mechanistic understanding and quantitative predictions of clinical DDIs based on endogenous biomarker observations, along with endogenous biomarker specific considerations on interpretations of the observed kinetics highlighted the complexity of DDGIs by presenting examples for various DDGI scenarios.

Henrike Bruckmüller, PhD

Professor Henrike Bruckmüller Elected as the Second Hartmut Derendorf Young Scientists Award Winner

At the 12th Marbach Castle DDI Workshop Henrike Bruckmüller, Postdoctoral Researcher at the Institute for Experimental and Clinical Pharmacology, Kiel University, Germany, and Associate Professor in Pharmacology, Department of Pharmacy, The Arctic University of Norway, Tromsø, Norway, was elected as the second Hartmut Derendorf Young Scientists Award Winner.

Her awarded lecture entitled “Drug-Drug-Gene Interactions (DDGIs)”, highlighted the complexity of DDGIs by presenting examples for various DDGI scenarios. In her presentation practical challenges and potential future strategies helping to pave the way to clinical implementation of DDGI recommendations were discussed.

Daniel Gonzales, PharmD, PhD

Professor Daniel Gonzales Elected as the First Hartmut Derendorf Young Scientists Award Winner

At the 11th Marbach Castel DDI Workshop Professor Daniel Gonzales (University of North Carolina at Chapel Hill, USA) was elected as the first Hartmut Derendorf Young Scientists Award Winner. His awarded lecture entitled “Application of Pharmacometric Approaches and Real-World Data to Characterize Drug-Drug Interactions in Infants and Children”, highlighted strategies to explore potential DDI susceptibilities in younger children using combination of clinical data and PBPK modelling.