The Workshop Programme 2026

Save the Date – DDI Workshop 2026

The upcoming Workshop will take place from May 31st to June 2nd, 2026.

In its 16th year, the Marbach Workshop brings together international experts to discuss current topics in drug-drug interactions. The 2026 event will update attendees on ­recent scientific advances and clinical applications.

The workshop starts Monday, June 1st, 2026, with Session I: DDI Implementation from Bench to Bedside. Presentations will cover challenges in applying research to clinical practice, especially for DDIs and pharmacogenomics. Academic and regulatory speakers will address knowledge gaps at drug approval, and industry experts will discuss personalized DDI management strategies.

Following a discussion at 2025 workshop with regard to publication of European Medicines Agency’s (EMA) opinion report on qualifying PBPK platforms for DDI prediction, the 2026 workshop will dedicate a session (Session II) where experts from EMA, UK’s MHRA, Certara, and J&J will reflect on review experience of regulator and software developer, and present stakeholders’ feedback on the first-of-its-kind PBPK qualification report.

On Tuesday, June 2nd, Session III covers managing complex drug interactions in vulnerable groups, including case studies from the COVID-19 pandemic and strategies for geriatric and underserved patient groups.

Session IV focuses on advancements in in vitro assays for non-CYP induction, discussing UGT induction, PBPK extrapolation, and CYP3A /UGT co-induction in DDI prediction.

Each session during the event will include interactive discussions, and participants may submit abstracts for poster presentations in Session V: Poster Session. The workshop provides an opportunity for exchanging information and networking.

The Workshop Organizers

Uwe Fuhr, MD
Amin Rostami-Hodjegan, PhD, FCP
Ping Zhao, PhD
Isabelle Ragueneau-Majlessi, MD
Dr. Wafaâ Jabrane

 


 

Workshop Programme 2025

Final Announcement

Marbach DDI Workshop 2025 – Final Announcement [PDF-Download | 1,8 MB]

Afternoon Individual Arrival & Check-in at Marbach Castle
03:00 p.m. Registration & Coffee
06:00 p.m. Oral Poster Presentation
07:30 p.m. Come Together Dinner
08:00 – 09:00 a.m. Registration & Coffee
09:00 – 09:15 a.m. Welcome Address and Introduction into the Workshop
Amin Rostami
Session I Caring for Individual Patient – DDI in Hospital Setting vs. Drug Development
Chair: Robert Hermann
09:15 – 09:45 a.m. Management of Metabolic and Transporter-Related DDI in Clinic:
Implementing PBPK in Clinical Setting as the First Step Towards ­Personalised Dosing
Youssef Daali, PhD, Geneva University Hospital, Geneva, Switzerland
09:45 – 09:55 a.m. Discussion
09:55 – 10:25 a.m. Disease Population vs Healthy Volunteers – Understanding Practicalities during Drug Development vs Clinical Landscape of DDIs
Kunal S. Taskar, PhD; GSK Medicines Research Centre, Hertfordshire, UK
10:25 – 10:35 a.m. Discussion
10:35 – 11:05 a.m. Networking and Poster Viewing Over Coffee Break
Session II Assessing Metabolic DDI via Static vs. Dynamic Modeling ­Approaches
Chair: Amin Rostami
11:05 – 11:35 a.m. Drug Development vs Clinical Management of Metabolic DDI – Static vs Dynamic Models – What to Use When and How?
Italo Poggesi, PhD; Clinical Pharmacology Modeling and Simulation, GSK Verona, Italy
11:35 – 11:45 a.m. Discussion
11:45 – 12:15 a.m. Optimal Use of Mechanistic Static Models in Clinical Development
Sheila Annie Peters, PhD; Boehringer Ingelheim, Ingelheim, Germany
12:15 – 12:25 p.m. Discussion
12:25 – 02:00 p.m. Networking Over Lunch
02:00 – 02:30 p.m. Assessing the Risk of Metabolic DDI for Wide Range of Patients – ­Static vs. Dynamic Models – One Step Forward and Two Steps Backwards!
Aki T. Heikkinen, PhD; Certara Predictive Technologies, Certara Inc, UK
02:30 – 02:40 p.m. Discussion
02:40 – 03:10 p.m. Expectations and Over-Expectations from Static Calculations of ­Metabolic DDI: Implications for FDA Decision Tree and Clinical Study Waivers for DDI
Yuching Yang, PhD; Durham, North Carolina, USA
03:10 – 03:20 p.m. Discussion
03:20 – 03:50 p.m. Networking and Poster Viewing Over Coffee Break
Session III Revisiting DDIs Caused by Cytokine Storm
Chair: Ping Zhao
03:50 – 04:20 p.m. Using PBPK to Manage Clinical DDI Caused by Cytokine Storm – ­Case Studies
Marie-Emilie Willemin, PhD; Johnson & Johnson, Beerse, Belgium
04:20 – 04:30 p.m. Discussion
04:30 – 05:00 p.m. Is PBPK Useful to Inform DDI Caused by Cytokine Storm? Resetting Expectation on Model Predictability (Invited)
Xinyuan (Susie) Zhang, PhD; Simulations Plus, Lancaster, CA, USA
05:00 – 05:30 p.m. Q&A and Discussions on the Sessions of the Day
07:00 p.m. Networking Over Dinner
Session IV Artificial Intelligence Support for the Research and ­Management of DDIs
Chair: Ping Zhao
08:30 – 09:00 a.m. From Techniques to Applications: How Natural Language ­Processing and AI, Including ChatGPT-like Models, Could Transform DDI ­Assessment
Sophia Ananiadou, PhD; University of Manchester, Manchester, UK
09:00 – 09:10 a.m. Discussion
09:10 – 09:40 a.m. Case Examples of AI Applications and Their Performance in Generating Specific DDI Information
Merel van Nuland, PharmD, PhD and Paul D. van der Linden, PharmD, PhD; Department of Clinical Pharmacy, Tergooi Medical Center, Hilversum, The Netherlands
09:40 – 09:50 a.m. Discussion
09:50 – 10:20 a.m. Networking and Poster Viewing Over Coffee Break
Session V Is There a Role for Microphysiological Systems in Preclinical DDI Studies
Chair: Andrew Parkinson
10:20 – 10:50 a.m. Microphysiological Systems: How MPS Platforms Advance Physio­logically-Relevant DDI Studies for Both Perpetrator and Victim Drugs
Murat Cirit, PhD; Javelin Biotech, Woburn, MA, USA
10:50 – 11:00 a.m. Discussion
11:00 – 11:30 a.m. Micro-Physiological Systems: How They Help to Improve Early ADME Predictions and Reduce the Data Gap in In Vitro to In Vivo Correlations
Amélie Moreau, PhD, Servier, Paris- Saclay, France
11:30 – 11:40 a.m. Discussion
11:40 – 12:10 a.m. Micro-Physiological Systems: What are the Potential Contexts of use in Drug-Drug and Drug-Natural Product Interactions
Edward J. Kelly, PhD; School of Pharmacy, University of Washington, Seattle, WA, USA
12:10 – 12:20 a.m. Discussion
12:20 – 02:00 p.m. Networking Over Lunch
Session VI Poster Session
Chair: Amin Rostami
02:00 – 03:00 p.m. Short Presentation & Discussion of Selected Posters
03:00 – 03:30 p.m. Networking and Poster Viewing Over Coffee Break
03:30 – 04:00 p.m. Q&A and Discussions on the Sessions of the Day
04:00 – 04:15 p.m. Concluding Remarks – Amin Rostami
End of Meeting & Departure
Last Update: 11.02.2025